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K O U D I N O V S
C I E N T I F I C C O R R E S P O N D E N C E
[ 2003 | 2002 |
2001
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(click on arrows to read letters): |
Papers under discussion: |
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Letter to colleagues: Articles on Alzheimer's in Science magazine: amyloid beta road show? / Dana Alliance lecture on neuroethics. Followed by reply by Petern Stern, Science Senior Editor. ( Click on the title above to open an Acrobat .PDF imprint of the correspondence. Acrobat reader required ) Alexei R. Koudinov Become public 4 November 2003 |
Monsonego A and Weiner H.
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Amyloid beta road show, or Has the lure of profits corrupted Alzheimer’s neuroscience? Alexei R. Koudinov Published online 5 August 2003; Current
hit parade: 1739
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Monsonego A et al.
Eriksen JL et al.
Cirrito JR, Holtzman DM.
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Cholesterol and Alzheimer's: is amyloid beta a cause or consequence of the disease? Alexei R. Koudinov (Published online 30 July 2003; Current hit parade: 703) Original ( 321 words 5 citations) letter was first electronically
submitted on July 22, 2003 as correspondence to Neurology. It was then
rejected on July 30, 2003. Neurology rejection letter stated: We
do not think the letter warrants publication as it does not add any substantial
contribution to the literature.
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Pappolla MA et al. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology 22 July 2003 61: 199-205.
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Amyloid beta and Alzheimer's disease: an endpoint relation? Alexei R. Koudinov Published online 13 July 2003; Current
hit parade: 678
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Sunderland T et al.
Ronald and Nancy Reagan Research Institute of the Alzheimer's
Association and the NIA working group: consensus report of the working
group on: "molecular and biochemical markers of Alzheimer's disease.
Thies B, Truschke E, Morrison-Bogorad M, Hodes RJ.
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Open letter to Donald Kennedy, Science Editor-in-Chief: AAAS, Science, Alzheimer’s disease and academic dishonesty. On August 8, 2003 I noticed that this letter was removed from SAGE KE. Unhappy to know? Then ask SAGE KE editor when it will be back at SAGE KE. Meanwhile the original letter is available at this link and at Science SAGE KE logo above. Alexei R. Koudinov Published online 16 June 2003; Current
hit parade: 1192
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Bloom FE.
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22 May 2003 Neuron article on Alzheimer's : 'valid research' or a
'drug company propaganda'?
(Submitted/published online 31 May / 1 June 2003; Current hit parade: 1899) Hasta la vista, amyloid cascade hypothesis, OR will academic dishonesty yield Alzheimer's cure? Alexei R. Koudinov Published online 26 May 2003; Current
hit parade: 1203
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Hock C, et al.
Winblad B, Blum KI.
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Alzheimer's amyloid beta oligomers versus lipoprotein Ab. Alexei R. Koudinov Published online 1 May 2003; Current
hit parade: 631
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Kayed R, et al.
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Correspondence with Neuron editorial office (August 2002) ( Click on the title above to open an Acrobat .PDF imprint of the letter. Acrobat reader required ) Alexei R. Koudinov (A. Koudinov correspondence with Neuron (August 2002, two items) on the conflict of interest between Dennis J. Selkoe, M.D. service as Elan corporation director and academic service as Neuron Editorial board member, and an author of an article missing competing interest disclosure) |
Selkoe DJ.
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Correspondence with Murray Sagsveen (Nov. 2002-March 2003) ( Click on the title above to open an Acrobat .PDF imprint of the correspondence. Acrobat reader required ) A. Koudinov correspondence with AAN (13 Nov. 2002 - 26 March 2003, eight items) on the conflict of interest between Dennis J. Selkoe, M.D., service as a chairperson for Potamkin Prize for Alzheimer's disease, Pick's disease and related disorders and D. Selkoe service as Elan corporation director ( Become public on 27 March 2003; July 1, 2003 hit parade: 225) Also see: A. Koudinov Feb 28, 2003 letter to Science Editor-in-Chief . |
Murray G. Sagsveen, General Counsel and Associate Executive
Director,
Rosenberg RN.
The Potamkin Prize for Research in Pick's, Alzheimer's
and Related disorders. The winner history 2002 edition
News release: 2002 Potamkin Prize Recognizes The Ground-Breaking
Work Of Alzheimer?s Disease Researchers In Germany, Belgium
Press release: Christian Haass, PhD, 2002 Potamkin Prize
co-recipient
2003 Potamkin Prize Shared By Two Researchers.
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Alexei R. Koudinov, M.D., Ph.D. (published online 22 November 2002)
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Kamenetz F. et al. APP Processing and Synaptic Function. Neuron 27 March 2003 37: 925-937. [ Abstract/FullText ] [ AlzForum News Report ]
Activity dependent secretion of b-amyloid: roles of b-amyloid in synaptic transmission. Soc Neurosci Abstr 2000 26: 491. [ Abstract at Scholarone ]
Amyloid beta, neural lipids, cholesterol and Alzheimer's disease. Neurobiol Lipids 4 March 2003 1: 6 [ Free FullText ]
Amyloid beta protein restores hippocampal long-term potentiation: a central role for cholesterol? Neurobiol Lipids 2003 1: 8 In Press [ Abstract ]
Evidence that synaptically released b-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci 15 Nov 2002 22: 9785-93. [ PubMed ] |
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Alzheimer's disease vaccine danger: take it straightforward, not double-edged
(Submitted/published online 22/23 March 2003; Current hit parade: 1215) |
Greenberg SM, Bacskai BJ, Hyman BT.
Nicoll JAR et al.
Check E.
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Letter to Donald Kennedy (28 Feb 2003) ( Click on the title above to open an Acrobat .PDF imprint of the letter. Acrobat reader required ) Alexei R. Koudinov (E.mailed to Dr. Kennedy on 28 February 2003 / Become public on 20 March 2003; July 1, 2003 hit parade: ) |
Donald Kennedy, Editor-in-Chief, Science magazine, Correspondence with A. Koudinov, June - Dec. 2002
Also see: A. Koudinov
Jan. 31, 2003 Science dEbate letter .
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Open letter to Public Citizen's Health Research Group on Alzheimer's disease research. Alexei R. Koudinov SAGE KE letter published online 21 February 2003. BMJ letter first submitted 17 February; re-submitted 20 February; published 27 February 2003 Joint current hit parade:
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Laura Helmuth.
Laura Helmuth.
Also see: Barbehenn E, Lurie P, Wolfe SM.
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Do not underscore the epidemics of the business, too. ( Click on the title above to open an Acrobat .PDF imprint of the submitted dEbate letter. Acrobat reader required ) Alexei R. Koudinov Submitted on 31 Jan 2003 as Science dEbate letter.
The rejection letter stated:
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Donald Kennedy Editorial: An epidemic of politics. Science 31 Jan 2003 299(5607): 625
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Health News Readers' Opinion Alzheimer's research: New ideas or old dogma?
Health News Readers' Opinion Cholesterol and Alzheimer's: beware of oversimplification.
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Gina Kolata New Ideas Energize Alzheimer's Battle. The New York Times (Health News) January 14, 2003 [ Full Text ] |
Does Rotterdam study question the link between fat and dementia?
(submitted online 27 December 2002/Published online 15
January 2003; Current hit parade: 500)
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Engelhart MJ et al.
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| eLetters
(click on arrows to read letters): |
Papers under discussion: |
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Amyloid was never clearly implicated in Alzheimer's disease, so look at Ab from a different angle. Alexei R. Koudinov (submitted/published online 26/30 November 2002; Current hit parade: ) The early version of this BMJ letter was first
submitted (20 Nov 2002, and then rejected) to J. Clin. Invest. as
eLetter to editor for article by D. Selkoe cited to the right.
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Selkoe DJ.
Golde TE.
Selkoe DJ.
Wolfe MS.
Haass C.
Citron M.
Selkoe DJ, Schenk D.
Colin L Masters and Konrad Beyreuther
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Ethical Conundrums : An Alzheimer's case.
Also, see the .PDF imprint of the original dEbate letter submitted to Science, and then rejected. (submitted/published online 8/12 September 2002; Current hit parade:
Amyloid hypothesis: summer 2002 and 8th International Conference
on Alzheimer’s disease update.
(submitted/resubmitted online 29/30 July 2002; published
online 31 July 2002; Current hit parade: )
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Science for Sale : A Harvard researcher stands to profit from a product he "independently" reviewed for the National Institutes of Health. The Boston Phoenix, Published 29 April 1999 [ Full Text ] Crowley D.
John Hardy, Dennis Selkoe.
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Alzheimer's disease and amyloid beta protein. Alexei R. Koudinov, Mark A. Smith, George Perry & Natalia V. Koudinova (submitted/published online 14/25 June 2002; Current hit parade: 3142)
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J. Paul Taylor, John Hardy, Kenneth H. Fischbeck.
Walsh DM, Klyubin I, Fadeeva JV, et al.
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| Expert readers feedback on the above letters by Koudinov
et
al:
"... thanks for your making another strong statement about the realities involving the amyloid hypothesis..." "...Thanks for pointing this out." "Excellent letter. I totally agree with your position. Hopefully in the near future scientists that are part of study sections scoring grants will value the importance of research projects characterizing the normal physiological role(s) of amyloid beta and other fragments of APP." "I have been in this field for over 15 years and I agree with you that the amyloid theory of AD is far from clear... We clearly need a better theory for explaining this disorder" "Finally, after 15 years of "bad" amyloid maybe somebody will look at the function..." |
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Beware the simplification in defining neurodegenerative diseases. Alexei R. Koudinov & Natalia V. Koudinova
(Published online 23/25 June 2002; Current hit parade: 766) |
Adrian Williams
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Alzheimer’s amyloid dogma. A time for change Alexei R. Koudinov, Mark A. Smith, George Perry, Natalia V. Koudinova (submitted/published online 21 June 2002; Current hit parade: 864) |
Lawrence I Golbe
J. Paul Taylor, John Hardy, Kenneth H. Fischbeck.
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Amyloid hypothesis, synaptic function, and Alzheimer’s disease, or Beware: the dogma is revitalized. Alexei R. Koudinov, M.D., Ph.D., &
(Submitted/published online 14/15 May 2002; First submitted to Nature on April 12 and April 24, 2002; Current hit parade: 1993)
( Click on the title above to open an Acrobat .PDF imprint of the letter. Acrobat reader required ) Alexei R. Koudinov (A. Koudinov correspondence with Nature on the non-disclosure of Dennis J. Selkoe conflict of interest (as Elan corporation director) in the Nature article under discussion. |
Walsh DM, Klyubin I, Fadeeva JV, et al.
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Alzheimer’s anti-amyloid vaccination and statins: two approaches, one dogma. The time for change. Alexei R. Koudinov, M.D., Ph.D., &
(Submitted/published online 20 March 2002; Current hit parade: 2774) |
Check E.
Wiebe S and Nicolle MW
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(a .PDF imprint of submitted letter. Acrobat reader required) Alzheimer's amyloid beta: is it really bad.
(submitted online 19 March 2001; originally e-submitted
to Science on March 13, 2001)
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Marx J.
Simons M, Keller P, Dichgans J, Schulz JB.
Wolozin B.
... and a list of other articles on Cholesterol
and amyloid, see the eLetter .PDF imprint for refs.
Also see our BMJ eLetter of March 2002. |
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Cholesterol homeostasis failure at neuromuscular junctions and CNS
synapses: a unifying cause of synaptic degeneration ?
(submitted online 20 February 2002/Published online 26
February 2002; Current hit parade: 668)
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Jaworska-Wilczynska M et al.
Naguib M et al.
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Genetics/cardiovascular risk versus environment/Alzheimer's: directions
diverted, cholesterol united
(submitted/published online 14 December 2001; updated 2 January 2002; Current hit parade: 1376) |
Day INM & Wilson DI
Grant WB et al.
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Cholesterol misregulation causes Alzheimer's disease: diet likely involved. Alexei R. Koudinov & Natalia V. Koudinova. (submitted/published online 1 December 2001) |
Titan et al. Frequency of eating and concentrations of serum cholesterol in the Norfolk population of the European prospective investigation into cancer (EPIC-Norfolk): cross sectional study. BMJ 2001 323: 1286. [ Full Text ] |
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High density lipoproteins as hidden imprint of Alzheimer's brain
cholesterol pathology.
(submitted online 27 November 2001/published online 12
December 2001)
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Launer LJ et al. Cholesterol and neuropathologic markers of Alzheimer's disease: a population-based autopsy study. Neurology 2001 57: 1447-52. [ PubMed ] [ Full Text ]
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[ PubMed ] Cholesterol's role in synapse formation.
(submitted online 2:52 am, Jerusalem time, 9 November 2001; published 22 March 2002; also see .PDF imprint of the submitted letter) |
Barres BA, Smith SJ. Cholesterol-Making or Breaking the Synapse. Science (9 Nov 2001) 294: 1296-1297 [ PubMed ] [ Full Text ]
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Looking forward for a historic issue, or: Is there anything besides amyloid? Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D., Ph.D. (published online 19 October 2001) |
Kale R. Neurodegenerative disorders. BMJ 2001 323: 879. [ Full Text ]
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Cholesterol, synaptic function and Alzheimer's disease? Alexei R. Koudinov, M.D., Ph.D., &
(published online 16 October 2001; First submitted to
Nature Cell Biology on Ocober 8, 2001 )
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Puglielli L, et al. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid b-peptide. Nature Cell Biol 2001 10: 905-12 [ PubMed ] [ Full text ]
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[ PubMed ] Beware: the link is not simple.
(submitted online 1 October 2001/published online 16 October
2001)
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Marx J. Alzheimer's disease: bad for the heart, bad for the mind? Science (19 October 2001) 294: 508-509 [ PubMed ] [ Full Text ]
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LRP: a cholesterol recruitment checkpoint for neuronal structure-functional plasticity? Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D., Ph.D. (published online 12 October 2001)
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Herz J, Strickland DK. LRP: a multifunctional scavenger and signaling receptor. J Clin Invest 2001 108: 779-84. [ PubMed ] [ Full Text ]
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Alzheimer's pathogenesis: tau and amyloid - a consensus or a challenge for a third party quest? [ .PDF imprint of original Science dEbate eLetter ] Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D., Ph.D. (published online 4 September 2001/First submitted to Science as dEbate eLetter to editor on 24 August 2001 |
Gottlieb S. Scientists propose a new theory for the pathogenesis of Alzheimer's disease. BMJ 2001 322: 1085 [ Full Text ]
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Dementia, cholesterol and the soft science of dietary fat. Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D., Ph.D. (published online 27 July 2001) |
Gottleib S. Statins can help prevent dementia. BMJ 2000 321: 1241a [ Full Text ]
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Pioneering new era of biomedical science publishing. Alexei R. Koudinov, M.D., Ph.D. (published online 8 October 2001) |
News: Medical editor lambasts journals and editors. BMJ 2001 323: 651. [ Full Text ] |
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Electronic Public Library of Science?
(published online 31 May 2001) |
Mellman I. Considerations in Creating Online Archives. Science 2001 292: 51b. [ Full Text ] |
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